What Are the Applications of Ion-Exchange Solid Phase Extraction?

Ion-exchange solid phase extraction is widely used in biological samples and environmental monitoring.

During the extraction process, the pH of the sample is adjusted so that the solute is easily ionized. The solute is exchanged from the resin by changing the pH or increasing the strength of the competing ions during elution.

The pH of the organic base or acid is 50% protonated or ionized near the pKa. If the pH of the two units is lowered or increased, respectively, 99% of the base or acid is ionized, so the elution should also be increased or Lower the pH of the two units.

The sensitivity of ion exchange solid phase extraction is affected by pH, interionic force, flow rate and buffer ionic strength. The higher the competitive ionic strength in the sample matrix, the lower the extraction efficiency. For example, citric acid can compete for anion exchange sites.

In addition, some adsorbents can chelate with certain metal ions, such as iminodiacetic acid and Na+, which can effectively separate certain metal ions. Hawach offers you ion-exchange solid phase extraction cartridges.