The Concept and Basic Principles of Solid Phase Extraction

Solid Phase Extraction (SPE) is a sample preparation technology developed since the mid-1980s. It is developed by a combination of liquid-solid extraction and liquid chromatography. The separation, purification and enrichment of the sample are achieved mainly by the selective adsorption and desorption process of the sample components by the solid phase filler. The main purpose is to reduce sample matrix interference and improve detection sensitivity.
The basic principles and methods of solid phase extraction:
SPE technology is based on liquid-solid phase chromatography theory. It uses selective adsorption and selective elution to enrich, separate and purify samples. It is a physical extraction process that includes both solid and solid phases. It can also be approximated. Think of it as a simple chromatographic process.
Solid phase extraction (SPE) is a separation principle using liquid chromatography using selective adsorption and selective elution. The more common method is to pass a liquid sample through an adsorbent, retain the substance to be tested, and then use an appropriate strength solvent to wash away the impurities, and then elute the test substance with a small amount of good solvent, thereby achieving the purpose of rapid separation, purification and concentration. It is also possible to selectively adsorb the interfering impurities and let the measured substance flow out; or simultaneously adsorb the impurities and the north side substance, and then selectively elute the test substance with a suitable solvent.