Ion-Exchange SCX SPE Cartridge

Mechanism of action: SCX
Particle size: 40-75μm
Average pore size: 70Å
Surface area: 510 m 2/g
Volume: 3mL, 6mL, 12mL

Availability: In Stock


Extracting Basic Compounds

Description of SCX SPE Cartridge

Strong cation exchange(SCX) SPE cartridge is a silica-based benzenesulfonic acid-based filler. Its negatively charged sulfonic acid group has a strong cation exchange capacity, and the benzene ring has certain hydrophobic retention. SCX extracts positively charged basic compounds such as amines.


  • Lower pKa.
  • Strong cation exchange and reversed double retention;
  • SCX cartridges are particularly useful for the isolation of positively charged molecules, such as peptides, proteins, amino acids, and other charged species.
  • The binding capacity of SCX SPE cartridges depends on factors like sample pH, ionic strength, and the specific resin used.
  • By adjusting the pH value, the charged state of the sulfonic acid group can be changed to facilitate elution.

Application of SCX Cartridge

  • Detection of drug abuse, such as amphetamine;
  • Analysis of drugs and their metabolites in biological matrices;
  • Detection of pesticides and antibiotic residues in foods, such as macrolides.
  • Used for the purification and concentration of proteins and peptides with cationic charges, aiding in proteomic studies and mass spectrometry analysis.
  • Isolate and purify cationic drug compounds and metabolites from biological samples for pharmaceutical analysis.
  • Extract and preconcentrate cationic contaminants, such as heavy metal ions, from water and soil samples.
  • Separate and analyze cationic compounds like amino acids and certain additives in food and beverages.

Relevant Standards

NY/T 468-2006 Determination of Clenbuterol in Animal Tissues by Gas Chromatography-Mass Spectrometry.


Technical Data

SpecificationMaximum Sample LoadVolumeMinimum Elution Volume

Ordering Information

Item   No. SpecificationPackage (pcs/pk)
SLSPE301SCXSCX, 40-75μm, 70Å, 30mg/1mL100
SLSPE1001SCXSCX, 40-75μm, 70Å, 100mg/1mL100
SLSPE603SCXSCX, 40-75μm, 70Å, 60mg/3mL50
SLSPE2003SCXSCX, 40-75μm, 70Å, 200mg/3mL50
SLSPE5003SCXSCX, 40-75μm, 70Å, 500mg/3mL50
SLSPE2006SCXSCX, 40-75μm, 70Å, 200mg/6mL30
SLSPE5006SCXSCX, 40-75μm, 70Å, 500mg/6mL30
SLSPE1K6SCXSCX, 40-75μm, 70Å, 1g/6mL30
SLSPE2K12SCXSCX, 40-75μm, 70Å, 2g/12mL20
SLSPE502SCXSCX, 40-75μm, 70Å, 50mg/2ml/w96w
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